Hu p107 Pure SD9 100ug

• 产品编号：BD-554209      品牌：BD-Pharmingen       原厂货号：554209
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

p107 is a cellular protein that, like the retinoblastoma protein (Rb), can bind SV40 large T antigen and adenovirus E1A. It was originally
described as an E1A-associated protein that was detected in extracts of the 293 adenovirus transformed human kidney cell line. p107 and Rb
share sequence homology which mainly extends throughout their large T/E1A binding pockets. In cells that do not contain the viral
oncogenes, p107 and Rb associate, independently, with cellular E2F. E2F, originally identified as an activator of the adenovirus E1A
promoter, is a transcription factor. It is believed that E2F plays a role in the control of cellular genes that respond to proliferation signals. In
vivo, the large T/E1A binding pocket of Rb, associates with E2F primarily in G1 and S phase. p107 forms two complexes with E2F, one in S
phase with cdk2 and cyclin A, and one in G1 phase with cdk2 and cyclin E. In vitro, the pocket regions of p107 and Rb associate with the
same set of proteins, except that p107 also associates with two additional proteins, one of which is cyclin A. Since p107 shares structural and
biochemical features with Rb it has been suggested that p107, like Rb, is a tumor suppressor gene product; however, the biological function of
p107 remains speculative. The SD9 clone has been reported to be crossreactive on monkey and mouse p107. It reportedly does not crossreact
with Rb. Reports of epitope mapping have shown that SD9 recognizes a region between amino acids 414-653 of human p107.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.