Hu Cyclin D3 Pure G107-565 100ug

• 产品编号：BD-554195      品牌：BD-Pharmingen       原厂货号：554195
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes.
Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. The main
cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1
(G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small proteins that
bind to cyclins, cdks, or cyclin-cdk complexes, e.g., p21 and p27Kip1. Specific substrates for cdk-cyclin complexes include nuclear lamins,
histones, oncogenes (c-src, c-abl, SV40 large TAg), tumor suppressor genes (e.g., retinoblastoma protein [Rb] and p53), nucleolin, RNA
polymerase II and others. It is thought that D-type cyclins are involved in regulating the passage of mammalian cells through G1. The reduced
molecular weights of D-type cyclins are as follows: cyclin D1 (36 kDa), cyclin D2 (35 kDa) and cyclin D3 [31 and 34 kDa (doublet)].
G107-565 recognizes human cyclin D3. It does not cross-react with human cyclins D1 or D2.
 

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.