Ms CD49d Pure 9C10(MRF4.B) 500ug

• 产品编号：BD-553314      品牌：BD-Pharmingen       原厂货号：553314
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

原厂资料：

The 9C10 (MFR4.B) antibody reacts with the integrin α4 chain (CD49d), which is expressed as a heterodimer with either of two β chains, β1
or β7. The α4β1 integrin (VLA-4, CD49d/CD29) is expressed on most peripheral lymphocytes, thymocytes, and monocytes; while the α4β7
integrin (LPAM-1) is expressed on peripheral lymphocytes, but on only a small subset of thymocytes. These integrins mediate a variety of
cell-cell and cell-matrix interactions, recognizing the ligands VCAM-1 (CD106) and fibronectin. Integrin α4β7 also preferentially binds to the
mucosal vascular addressin, MAdCAM-1. Although the 9C10 (MFR4.B) antibody alone has been reported to have little function-blocking
activity, it can augment the inhibitory effects of mAb R1-2 (Cat. No. 553153), resulting in almost complete inhibition of VLA-4 binding to
VCAM-1.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Store undiluted at 4°C.