Ms CD3e NALE 145-2C11 500ug

• 产品编号：BD-553057      品牌：BD-Pharmingen       原厂货号：553057
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

145-2C11抗体可与表达于胸腺细胞、成熟T淋巴细胞和NK-T细胞的T细胞受体交联的CD3复合物的25-kDa的ε链发生反应。CD3e的胞质段参与抗原识别后发生的信号转导事件，可激活多个细胞生化途径。可溶性145-2C11抗体在体内或体外可激活Naive T细胞或记忆T细胞。在某些情况下，145-2C11抗体活化T细胞后可导致细胞凋亡。145-2C11抗体不与大鼠白细胞发生交叉反应。

原厂资料：

The 145-2C11 antibody reacts with the 25-kDa ε chain of the T-cell receptor-associated CD3 complex, which is expressed on thymocytes, mature T lymphocytes, and NK-T cells. The cytoplasmic domain of CD3e participates in the signal transduction events which activate several cellular biochemical pathways as a result of antigen recognition. Soluble 145-2C11 antibody can activate either unprimed (naive) or primed (memory/preactivated) T cells in vivo or in vitro, in the presence of Fc receptor-bearing accessory cells. In contrast, plate-bound 145-2C11 can activate T cells in the absence of accessory cells. Soluble 145-2C11 antibody has been reported to induce re-directed lysis of Fc receptor-bearing target cells by CTL clones and can also block lysis of specific target cells by antigen-specific CTL's. Under some conditions, T-cell activation by 145-2C11 antibody has been reported to result in apoptotic cell death. The 145-2C11 antibody does not cross-react with rat leukocytes and it has been reported that pre-incubation of thymus cell suspensions at 37°C for 2-4 hours prior to staining enhances the ability of anti-CD3ε and anti-αβ TCR mAbs to detect the T-cell receptor on immature thymocytes.

注意事项：

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Store undiluted at 4°C.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
This preparation contains no preservatives, thus it should be handled under aseptic conditions