BD IMag™ anti-mouse CD45R/B220 Particles - DM are magnetic nanoparticles that have monoclonal antibody conjugated to their surfaces.
These particles are optimized for the positive selection or depletion of CD45R/B220-bearing leukocytes using the BD IMagnet™.
CD45R/B220 is reportedly expressed on B lymphocytes at all stages from pro-B through mature and activated B cell. It is also has been
reported to be found on abnormal T cells involved in the lymphadenopathy of lpr/lpr and gld/gld mutant mice, on lytically active subsets of
lymphokine-activated killer cells (NK cells and non-MHC-restricted CTL), on apoptotic T lymphocytes of mice injected with bacterial
superantigen, on a population of NK-cell precursors in the bone marrow, and on B-lymphocyte, T-lymphocyte, and macrophage progenitors in
fetal liver. The CD45R/B220 antigen is reportedly not on hematopoietic stem cells, plasma cells, resting T lymphocytes, or MHC-restricted
CTL.