Interleukin 2 was discovered through its function as a T cell growth factor (TCGF). IL-2 binds to IL-2 receptor which isexpressed in T and B cells, thymocytes, and NK cells. The IL-2 receptor comprises three distinct components: the a -chain, which is cytokine specific, and the b- and gc-subunits which are share with the IL-15 receptor. In addition, the g c-subunit is a component of a series of other cytokine receptors, these being members of the gc cytokine receptor family (IL-4, IL-7, IL-9, and IL-21) . IL-2 signaling may play a major role in the differentiation of regulatory T cells . IL-2, IL-15, and IL-7 can all support NK cell differentiation; nevertheless, analyses of IL-2(-/-), IL-2Ra(-/-) mice fail to exhibit significant defects in NK cell development. This data suggest that IL-2 might have a redundant role in NK cell differentiation.
原厂资料：
Description:
Interleukin 2 was discovered through its function as a T cell growth factor (TCGF). IL-2 binds to IL-2 receptor which isexpressed in T and B cells, thymocytes, and NK cells. The IL-2 receptor comprises three distinct components: the a -chain, which is cytokine specific, and the b- and gc-subunits which are share with the IL-15 receptor. In addition, the g c-subunit is a component of a series of other cytokine receptors, these being members of the gc cytokine receptor family (IL-4, IL-7, IL-9, and IL-21) . IL-2 signaling may play a major role in the differentiation of regulatory T cells . IL-2, IL-15, and IL-7 can all support NK cell differentiation; nevertheless, analyses of IL-2(-/-), IL-2Ra(-/-) mice fail to exhibit significant defects in NK cell development. This data suggest that IL-2 might have a redundant role in NK cell differentiation.
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