TNF-a is released from macrophages, monocytes, neutrophils, T-cells (principally CD4+), NK-cells and many transformed cell lines. Soluble homotrimeric TNF-a is released from cells by proteolysis of the integral membrane precursor form of TNF-a. TNF-a binding to some TNF-a receptors induces apoptosis and depending on cell type, receptor expression, and signal transduction status can induce other responses. TNF-a is involved in the inflammatory response.
原厂资料：
Description:
TNF-a is released from macrophages, monocytes, neutrophils, T-cells (principally CD4+), NK-cells and many transformed cell lines. Soluble homotrimeric TNF-a is released from cells by proteolysis of the integral membrane precursor form of TNF-a. TNF-a binding to some TNF-a receptors induces apoptosis and depending on cell type, receptor expression, and signal transduction status can induce other responses. TNF-a is involved in the inflammatory response.
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