IL-1 was isolated from human blood that had been exposed to a pathogenic bacterium. IL-1 is a pyrogen, and it is an activating factor for lymphocytes. It also damaged joints and influenced liver proteins . IL-1a binds to the cell surface type I and II IL-1 receptors (IL-1RI and IL-1RII). IL-1 and -b and IL-1RA can compete for binding to these receptors. However, only IL-1RI, not IL-1RII, is functional because IL-1RII lacks a cytoplasmic domain and is thus unable to transmit signals to downstream steps. IL-1a is expressed by cancer cells and promotes angiogenesis and metastasis of pancreatic cancer and human gastric cancer cell lines. In addition, IL-1 induced the expression of VEGF in colon cancer.
原厂资料：
Description:
IL-1 was isolated from human blood that had been exposed to a pathogenic bacterium. IL-1 is a pyrogen, and it is an activating factor for lymphocytes. It also damaged joints and influenced liver proteins . IL-1a binds to the cell surface type I and II IL-1 receptors (IL-1RI and IL-1RII). IL-1 and -b and IL-1RA can compete for binding to these receptors. However, only IL-1RI, not IL-1RII, is functional because IL-1RII lacks a cytoplasmic domain and is thus unable to transmit signals to downstream steps. IL-1a is expressed by cancer cells and promotes angiogenesis and metastasis of pancreatic cancer and human gastric cancer cell lines. In addition, IL-1 induced the expression of VEGF in colon cancer.
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