LT-a, also known as TNF-b, is a potent mediator of inflammatory and immune responses. It belongs to the TNF superfamily of ligands and signals through TNFR1 and TNFR2. LT-a is produced by activated T and B lymphocytes, and has similar activities to TNF-a. Like TNF-a, LT-a (TNF-b) is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. LT-a is secreted as a soluble polypeptide, but can form heterotrimers with LT-b, which effectively anchors the LT-a to the cell surface. LT-a is cytotoxic to a wide range of tumor cells. Recombinant human LT-a is secreted 171 amino acid protein (18.6 kD) which forms an active non-disulfide linked homotrimer structure in solution.
原厂资料：
Description:
LT-a, also known as TNF-b, is a potent mediator of inflammatory and immune responses. It belongs to the TNF superfamily of ligands and signals through TNFR1 and TNFR2. LT-a is produced by activated T and B lymphocytes, and has similar activities to TNF-a. Like TNF-a, LT-a (TNF-b) is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. LT-a is secreted as a soluble polypeptide, but can form heterotrimers with LT-b, which effectively anchors the LT-a to the cell surface. LT-a is cytotoxic to a wide range of tumor cells. Recombinant human LT-a is secreted 171 amino acid protein (18.6 kD) which forms an active non-disulfide linked homotrimer structure in solution.
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