Interleukin-28 (IL-28, IFN-λ2, IFN- λ3) is a class II cytokine receptor ligand distantly related to type I interferons (IFNs) and the IL-10 family. IL-28 has two isoforms, IL-28A (IFN-λ2) and IL-28B (IFN-λ3) that are similar in amino acid sequence to IL-29 (IFN-λ1), as IL-29 shows 81% homology with IL-28A. IL-28 and IL-29 are produced by human peripheral blood mononuclear cells and dendritic cells upon viral infection, LPS stimulation, TLR stimulation, stimulation with poly(I:C) and other inducers of type I interferons. IL-28 and IL-29 both play a role in the interferon-mediated immune defense against viruses and up-regulate MHC class I antigen expression.
The BioLegend LEGEND MAX™ Human IL-28A (IFN-l2) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a capture antibody. This kit is specifically designed for the accurate quantitation of human IL-28A (IFN-l2) from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated with ready-to-use reagents.
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Introduction:
Interleukin-29 (IL-29, IFN-λ1) is a class II cytokine receptor ligand distantly related to type I interferons (IFNs) and the IL-10 family. IL-29 is similar in amino acid sequence to IL-28A (IFN-λ2) and IL-28B (IFN-λ3) as IL-29 shows 81% homology with IL-28A. IL-28 and IL-29 are produced by human peripheral blood mononuclear cells and dendritic cells upon viral infection, TLR stimulation, and other inducers of type I IFNs. IL-28 and IL-29 play a role in the IFN-mediated immune defense against viruses and up-regulate MHC class I antigen expression.
The BioLegend LEGEND MAX™ Human IL-29 (IFN-l1) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a capture antibody. This kit is specifically designed for the accurate quantitation of human IL-29 (IFN-l1) from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated with ready-to-use reagents.