Human IL-22 (IL-10-related T cell-derived inducible factor) is produced by activated T cells and acts on nonimmune cells to regulate local tissue inflammation. As a product of the TH17 lineage of CD4+ effector lymphocytes, IL-22 plays a critical role in mucosal immunity as well as in the disregulated inflammation observed in autoimmune diseases. IL-22’s biological activity is initiated by binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with the soluble binding protein IL-22BP that share sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex are members of the class II cytokine receptor family. Two types of IL-22 binding receptors have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes.
The BioLegend LEGEND MAX™ Human IL-22 ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a capture antibody. This kit is specifically designed for the accurate quantitation of human IL-22 from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated with ready-to-use reagents.
原厂资料：
Introduction:
Human IL-22 (IL-10-related T cell-derived inducible factor) is produced by activated T cells and acts on nonimmune cells to regulate local tissue inflammation. As a product of the TH17 lineage of CD4+ effector lymphocytes, IL-22 plays a critical role in mucosal immunity as well as in the disregulated inflammation observed in autoimmune diseases. IL-22’s biological activity is initiated by binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with the soluble binding protein IL-22BP that share sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex are members of the class II cytokine receptor family. Two types of IL-22 binding receptors have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes.
The BioLegend LEGEND MAX™ Human IL-22 ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a capture antibody. This kit is specifically designed for the accurate quantitation of human IL-22 from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated with ready-to-use reagents.
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