Human TSLP (Thymic Stromal Lymphopoietin) is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps its biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and stromal or stromal-like cells. Human TSLP impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c+ dendritic cells. TSLP activated dendritic cells prime naïve T cells to a TH2 phenotype, which are strong producers of cytokines IL-13, IL-5, and TNF-α. TSLP also directly stimulates the production of TH2 cytokines by human mast cells. Finally, expression of TSLP has been linked to the pathogenesis of allergic inflammation such as atopic dermatitis and asthma via activating dendritic cells and mast cells that trigger an inflammatory TH2 response.
BioLegend’s LEGEND MAX™ Human TSLP ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a capture antibody. This is specifically designed for the accurate quantitation of human from cell culture supernatant, serum, plasma and other biological fluids. All kits are analytically validated with ready-to-use reagents.
原厂资料：
Introduction:
Human TSLP (Thymic Stromal Lymphopoietin) is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps its biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and stromal or stromal-like cells. Human TSLP impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c+ dendritic cells. TSLP activated dendritic cells prime naïve T cells to a TH2 phenotype, which are strong producers of cytokines IL-13, IL-5, and TNF-α. TSLP also directly stimulates the production of TH2 cytokines by human mast cells. Finally, expression of TSLP has been linked to the pathogenesis of allergic inflammation such as atopic dermatitis and asthma via activating dendritic cells and mast cells that trigger an inflammatory TH2 response.
BioLegend’s LEGEND MAX™ Human TSLP ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a capture antibody. This is specifically designed for the accurate quantitation of human from cell culture supernatant, serum, plasma and other biological fluids. All kits are analytically validated with ready-to-use reagents.
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