Human IL-12/IL-23 (p40) ELISA MAXTM Capture Antibody (200X)
Human IL-12/IL-23 (p40) ELISA MAXTM Detection Antibody (200X)
Human IL-12/IL-23 (p40) Standard
Avidin-HRP (1000X)
Instruction Sheet
Lot-Specific Instruction/ Analysis Certificate
描述：
Introduction:
BioLegend’s ELISA MAX™ Standard Sets contain the capture and detection antibodies, recombinant protein standard, and Avidin-HRP required for the accurate quantification of natural and recombinant human IL-12/IL-23 (p40).These sets are cost-effective and designed for experienced ELISA users. Optimization of reagent concentrations and assay conditions may be required.
IL-12 is secreted by activated B lymphocytes and macrophages as a 70 kD heterodimeric glycoprotein comprised of disulfide-bonded 35 kD and 40 kD subunits. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated macrophages and dendritic cells. The disulfide-linked p40 homodimer can bind to IL-12 receptors and antagonize the activities of bioactive IL-12. IL-12/IL-23 p40 monomer is secreted in vast excess of IL-12 p70 heterodimer; IL-12/IL-23 p40 monomer has no activity and is antagonistic to IL-12 p70 with only 1/10th the activity of p40 homodimer. The antibodies in the Human IL-12/IL-23 (p40) ELISA MAXTM Set react with the p40 subunit of human IL-12 and IL-23, as monomer and homodimer.
原厂资料：
Introduction:
BioLegend’s ELISA MAX™ Standard Sets contain the capture and detection antibodies, recombinant protein standard, and Avidin-HRP required for the accurate quantification of natural and recombinant human IL-12/IL-23 (p40).These sets are cost-effective and designed for experienced ELISA users. Optimization of reagent concentrations and assay conditions may be required.
IL-12 is secreted by activated B lymphocytes and macrophages as a 70 kD heterodimeric glycoprotein comprised of disulfide-bonded 35 kD and 40 kD subunits. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated macrophages and dendritic cells. The disulfide-linked p40 homodimer can bind to IL-12 receptors and antagonize the activities of bioactive IL-12. IL-12/IL-23 p40 monomer is secreted in vast excess of IL-12 p70 heterodimer; IL-12/IL-23 p40 monomer has no activity and is antagonistic to IL-12 p70 with only 1/10th the activity of p40 homodimer. The antibodies in the Human IL-12/IL-23 (p40) ELISA MAXTM Set react with the p40 subunit of human IL-12 and IL-23, as monomer and homodimer.
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