Non-ionic - containing no charge (polyoxyethylenes or alkyl glucosides). Non-ionic detergents are suited for solubilizing membrane proteins without altering biological activity. These non-denaturing, gentler detergents are ideal for studying the conformation and function of proteins because they keep secondary and tertiary structure intact. Non-ionic detergents efficiently separate hydrophilic proteins from membrane spanning, hydrophobic proteins.
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