AHP979 recognises an epitope within the C-terminal region (CT) of Dopamine Beta-Hydroxylase (DBH). DBH is a member of the copper type II, ascorbate-dependent monooxygenase family, which catalyzes the conversion of dopamine to norepinephrine, a key neurotransmitter in the central and peripheral nervous systems.
The effects of DBH plasma levels have been a focus area for both neurological and psychiatric disorders, including Parkinson’s disease, hypertension, depression, schizophrenia, drug abuse and stress.
Species Cross-Reactivity
Target Species
Cross Reactivity
Monkey
Yes
Mouse
Yes
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
ELISA
Flow Cytometry
Immunohistology - Frozen
Immunohistology - Paraffin
Immunoprecipitation
Western Blotting
1/1000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP979 detects a band of approximately 75kDa in human adrenal medulla cell lysates.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch.
Antiserum Preparation
Antisera to human Dopamine Beta-Hydroxylase (CT) were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
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