RABBIT ANTI GABA A RECEPTOR ALPHA 4 (C-TERMINAL)

AHP922 is specific for the alpha 4 subunit of rat gamma-aminobutyric acid A (GABA_A ) receptor. 

GABA_A receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABA_A site results in increased intracellular chloride concentration and hyperpolarization of the cell.

GABA_A receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression.

GABA_A receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).

Species Cross-Reactivity

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.

Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

AHP922 detects a band of approximately 64kDa in rat brain lysates.

Storage

Shelf Life

Antiserum Preparation

GO Terms

UniProt

Health And Safety Information

Regulatory