AHP663 recognises an epitope at the C-terminus of human amyloid precursor protein (APP).
APP is a 110-130kD transmembrane protein. Processing of APP by Beta-secretase gives rise to amyloidogenic beta-amyloid proteins, deposition of which are characteristic of Alzheimer disease.
APP exists in a number of isoforms. APP(695) is predominant in neuronal tissue, whilst APP(751) dominates elsewhere.
APP also inhibits Notch signaling through it’s interaction with NUMB.
Species Cross-Reactivity
Target Species
Cross Reactivity
Monkey
Yes
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
ELISA
Flow Cytometry
Immunohistology - Frozen
Immunohistology - Paraffin
Immunoprecipitation
Western Blotting
1/500 - 1/1000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Storage
Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.
Antiserum Preparation
Antisera to human APP were raised by repeated immunisations of rabbits with highly purified antigen.
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