AHP1923 specifically recognises human Annexin III (ANXA3), otherwise known as Lipocortin III, a calcium-dependent phospholipid-binding protein and member of the annexin family, which acts as an inhibitor of phospholipase A2, and is involved in the cleavage of inositol 1,2 cyclic phosphate to form inositol 1 phosphate.
Studies have shown that quantification of ANXA3 in patient urine can be used as a novel non-invasive biomarker for prostatic cancer, complementary to prostate specific antigen.
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
ELISA
Flow Cytometry
Immunohistology - Frozen
Immunohistology - Paraffin
Immunoprecipitation
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch.
Antiserum Preparation
Antiserum to human ANXA3 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
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