AHP1716T recognises the C-terminal of human TICAM-2 (TIR domain-containing adapter molecule 2, also known as TIRAP3, TIRP, TRAM or TRIF-related adapter molecule), a member of the Toll/interleukin-1 receptor family. This family also includes the Toll-like receptors (TLRs). TICAM-2 functions in LPS-TLR4 signalling to regulate the MyD88-independent pathway during the innate immune response to LPS. It also plays a role in the activation of NF-kappa-beta. TICAM-2 is expressed in a variety of tissues including spleen, prostate, testis, uterus, heart and pancreas.
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
Immunohistology - Frozen
10ug/ml
Western Blotting
0.5 - 2.0ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1716T detects a band of approximately 27kDa in PC-3 cell lysate.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.
Antiserum Preparation
Antiserum to human TICAM-2 (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
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