AHP1434 recognises human TBC1 domain family member 1 (TBC1D1), a 133 kDa nuclear protein. TBC1D1 is expressed in a range of tissues with expression being highest in the kidney, testis and in haematopoietic cells. TBC1D1 plays a role in the regulation of cell growth and differentiation. It also regulates insulin mediated GLUT4 translocation through its GAP activity and is a likely Akt substrate.
Specific mutations in the TBC1D1 gene have been reported in certain forms of severe human obesity.
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
ELISA
Flow Cytometry
Immunohistology - Frozen
Immunohistology - Paraffin
Immunoprecipitation
Western Blotting
2.0 - 4.0ug/ml
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1434 detects a band of approximately 140kDa in Daudi cell lysates.
Storage
Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
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