收藏本站
热门搜索: A3500  E1910  A1360  25200056  dmem  

RABBIT ANTI RAT GABA B RECEPTOR 2 (pSer783)

  • 产品编号:AHP1301      品牌:AbD Serotec       原厂货号:AHP1301
  • 产品分类:抗体 > 一抗 > 蛋白特异性一抗
  • 应用分类:
 
包装: 0.1 ml
运保温度: +4oC or -20oC
到货周期: 登录后查看
标准价: ¥客户可见
会员价: ¥客户可见
积分: 客户可见
 
登录之后可加入购物车购买,请您 
对比 收藏

运费与支付说明:

1.含干冰类产品有运费;

2. 必须现金付款或有信用额度的会员才可以直接发货,否则需要等待现金付款信息。

描述:

Specificity

AHP1301 specifically recognises the 102kDa transmembrane gamma-aminobutyric acid B (GABAB) receptor 2 (GABR2), when phosphorylated at Ser783. 

GABAB receptors are heterodimeric G-protein coupled receptors which are important mediators of slow neuronal inhibition in the mammalian central nervous system. The functional expression of GABAB receptors on plasma membranes is dependent upon the co-expression of GABR1 (gamma-aminobutyric acid B (GABAB) receptor 1) and GABR2. Studies have shown that the phosphorylation of GABR2 at the Ser783 site, by AMPK (5’AMP-activated protein kinase), is vital for enhancing the survival of neurons following ischemic brain injury.

Species Cross-Reactivity

Target Species Cross Reactivity
Bovine Expected from Sequence
Chicken Expected from Sequence
Human Expected from Sequence
Mouse Expected from Sequence
Primate Expected from Sequence
Xenopus Expected from Sequence

Application

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.

 

Application Name Yes No Not Determined Suggested Dilution
ELISA        
Flow Cytometry        
Immunofluorescence       1/500
Immunohistology - Frozen        
Immunohistology - Paraffin        
Immunoprecipitation        
Western Blotting(1)       1/1000
(1)
For the detection of phosphoproteins, tyrosine phosphatase inhibitors such as 1mM Sodium Orthovanadate should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Western Blotting

AHP1301 detects a band of approximately 102kDa in rat synaptic membrane cell lysates.

Storage

Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Shelf Life

12 months from date of despatch.

Antiserum Preparation

Antisera to GABAB receptor 2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

GO Terms

UniProt

Health And Safety Information

Material Safety Datasheet Documentation #10088 available at: 
http://www.abdserotec.com/uploads/MSDS/10088.pdf

Regulatory

For research purposes only

 


相关图片

说明书

参考文献

本产品可用于的实验

购此产品的人还购买了
最近浏览产品

京ICP备15036693号-2    京公网安备11010802025653    版权所有:北京逸优科技有限公司       1.69

 纠 错