Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tested Applications
Dilution *
Dot blot (DB)
0.1-1 µg/ml
ELISA (ELISA)
0.1-1 µg/ml
Immunohistochemistry (IHC)
1-5 µg/ml
Neutralization (Neu)
Assay Dependent
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB40 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35.
Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.
Background/Target Information
Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.
原厂资料：
注意事项：
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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