TQ2WS is designed to be a superior quencher to FAM, HEX, TET, JOE, TF2 and rhodamine 6G. TQ2WS has (a). much stronger absorption; (b). much higher quenching efficiency; and (c). versatile reactive forms with much greater water solubility than other existing quenchers for labeling oligonucleotides and peptides. This TQ2WS product is the most-water soluble and non-fluorescent quencher for labeling oligos and peptides. We have demonstrated that TQ2WS is extremely useful for enhancing the water solubility of hydrophobic peptides. TQ2WS, SE readily reacts with aliphatic amines including amino acids, peptides, amino-modified oligos and proteins