Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.
• Increase disease relevance by interrogating a purified and active full-length LRRK2 protein • Uncover novel compounds or hits specific to the full-length form • Advance Parkinson's research using the full-length protein and validated assays
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