MO IL-27 UNCOATED ELISA

• 产品编号：88-7274-22      品牌：invitrogen       原厂货号：88-7274-22
• 产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
• 应用分类：

描述：

Description: This mouse IL-27 Ready-SET-Go! ELISA Set (with or without high affinity binding ELISA microwell plates) contains the necessary reagents, buffers and diluents for performing quantitative enzyme linked immunosorbent assays (ELISA). This ELISA reagent set is specifically engineered for accurate and precise measurement of mouse IL-27 protein levels from samples including serum, and supernatants from cell cultures.This ELISA has 11.8% cross reactivity to the recombinant human IL-27 and no cross reactivity to the recombinant mouse IL-12 when spiked in excess (100ng/ml).

IL-27, a member of the IL-12 family, is a heterodimeric protein consisting of the p40-related protein Epstein-Barr virus-induced gene 3 (EBI3) non-covalently linked to an IL-12p35-related protein, p28 (also known as IL-30). IL-27 is produced by activated antigen presenting cells and mature dendritic cells. LPS-stimulated IL-27 production is dependent on the TLR4/MyD88 mediated pathway. IL-27 prevents the development of Th17 cells even in the presence of TGF-beta and IL-6, but it has little or no effect on committed Th17 cells. Recent studies indicate that IL-27 has potent anti-tumor activity. In vitro, IL-27 has been found to act directly on naïve CD8 cells, generating CTL with enhanced granzyme B expression. In vivo, IL-27 has been reported to augment CTL activity, inhibit tumor growth, and induce complete regression of primary and metastatic neuroblastoma tumors. It has been reported that IL-27 is critically involved in the induction of inflammation in rheumatoid arthritis.

Special Note: To ensure optimal results from this ELISA Ready-SET-Go! Set, please only use the components included in the set. Exchanging of components is not recommended as a change in signal may occur.

原厂资料：