Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Tested Applications
Dilution *
Immunofluorescence (IF)
1:250
Immunoprecipitation (IP)
2 ug
Western Blot (WB)
1:2000
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
730011 has successfully been used to detect SMARCA4 in mouse, human and rat.
730011 has been successfully used in western blotting and immunofluorescence to detect SMARCA4.
Background/Target Information
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene.
原厂资料：
注意事项：
For Research Use Only. Not for use in diagnostic procedures.
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