MEK2 ABFIN REC RB AB PUR 100 UG

Product Specific Information

This antibody is predicted to react with bovine, chicken, mouse and rat based on sequence homology.

ABfinity™ recombinant antibodies are rabbit monoclonal antibodies, unmatched for producing superior results. ABfinity™ antibodies are developed by immunizing animals, screening for functionality, cloning the immunogen-specific antibody genes into high-level mammalian expression vectors, produced on a large scale, and purified with Protein A. 

ABfinity™ monoclonal antibodies resemble rabbit monoclonals isolated from serum or produced by hybridomas, but demonstrate greater specificity and sensitivity. Because ABfinity™ recombinant antibodies are derived from cloned DNA sequences of the heavy and light antibody chains, they are not susceptible to cell-line drift or lot-to-lot variation, thus allowing for peak specificity and performance.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Background/Target Information

MEK2 belongs to the family of mitogen-activated protein kinase kinases that phosphorylate threonine and tyrosine residues within the activation loop of their MAP kinase substrates. The ERK1/2 MAP kinase signaling pathway is an integral part of cell proliferation control and is frequently activated in human colorectal cancer. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221 and is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.