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PHOSPHO-AKT1 (SER473) ANTIBODY 100 UG

 
包装:
运保温度: -20°C
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描述:

Details
Tested species reactivity Human , Mouse
Published species reactivity Human
Host / Isotype Rabbit / IgG
Class Monoclonal
Type Antibody
Clone 98H9L8
Immunogen A peptide corresponding to amino acids 468-477 of P31749.
Conjugate Unconjugated
Form Liquid
Concentration 0.5 mg/ml
Purification Protein A
Storage buffer PBS
Preservative 0.09% sodium azide
Storage Conditions Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Tested Applications Dilution *
ELISA (ELISA) 1-5 ug/ml
Flow Cytometry (Flow) 1-3µg x 10^6 cells
Immunocytochemistry (ICC) 1-2µg
Immunofluorescence (IF) 1-2µg
Immunohistochemistry (Paraffin) (IHC (P)) 0.5-2 ug/ml
Western Blot (WB) 1-3µg/ml

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

Published Applications  
Western Blot (WB) See 1 publications below

Product Specific Information

This antibody is predicted to react with bovine, canine, chicken, chimpanzee, equine, feline, rat, Rhesus monkey , Xenopus and zebrafish based on sequence homology.

ABfinity™ recombinant antibodies are rabbit monoclonal antibodies, unmatched for producing superior results. ABfinity™ antibodies are developed by immunizing animals, screening for functionality, cloning the immunogen-specific antibody genes into high-level mammalian expression vectors, produced on a large scale, and purified with Protein A. 

ABfinity™ monoclonal antibodies resemble rabbit monoclonals isolated from serum or produced by hybridomas, but demonstrate greater specificity and sensitivity. Because ABfinity™ recombinant antibodies are derived from cloned DNA sequences of the heavy and light antibody chains, they are not susceptible to cell-line drift or lot-to-lot variation, thus allowing for peak specificity and performance.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Background/Target Information

AKT also known as protein kinase B (PKB) or RAS-alpha, is an ubiquitous serine/threonine kinase that plays an important role in diverse biological responses such as regulation of metabolism, cell survival and growth by phosphorylating multiple proteins. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.

 


注意事项:

For Research Use Only. Not for use in diagnostic procedures. 
 


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