Description: The monoclonal antibody 10C2 recognizes human nestin (residues 1464-1614). Nestin is a 220-240 kDa Class VI intermediate filament protein that is expressed in stem cells of the developing nervous system, specifically the neuroepithelium and angiogenic cells, and progenitors of pancreatic islet and mesenchymal cells. Additionally, expression has been identified in a variety of tumors such as glioblastomas and pancreatic tumors. Nestin containing filaments upon differentiation are replaced by cell type specific intermediate filament proteins, such as GFAP. No co-reactivity to rodent nestins has been observed using 10C2 antibody.
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