Description: This MR10-2 monoclonal antibody reacts with the mouse T-cell receptor (TCR) V beta 9 chain. Composed of an a and ß chain, TCR specificity is typically determined by Va, Ja, Vb, Db, and Jb gene rearrangement. The MR10-2 antibody recognizes the V beta 9 chain on T cells from mouse strains with the b haplotype, including BALB/c, CBA/Ca, C3H/He, and C57BL. This gene is deleted in mice bearing the a (e.g., C57BR, C57L, SJL, and SWR) or c (e.g, RIII) haplotypes. T cells expressing V beta 9 are also deleted in mice expressing the minor lymphocyte stimulating (MIs)-1a antigen.
The MR10-2 antibody has been reported to activate V beta 9+ T cells.
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