4690-3999G detects human glutathione peroxidise (GSH-Px), a selenium-containing tetrameric enzyme found in mammalian erythrocytes. GSH-Px has an important role in protecting cellular and subcellular membranes from oxidative damage, and functions to detoxify peroxide though the reduction of hydrogen peroxide and organic peroxides.
An increase in GSH-Px in tumour cells may be associated with resistance to drugs that act by generating reactive oxygen species, for example doxorubicin.
Species Cross-Reactivity
Target Species
Cross Reactivity
Human
Expected from Sequence
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
ELISA
1/100 - 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.
Antiserum Preparation
Antisera to bovine glutathione peroxidase were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
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