Description: The 1A29 monoclonal antibody reacts with rat CD54, which is also known as intercellular adhesion molecule 1 (ICAM-1). In the immune system, this type I immunoglobulin (Ig)-like transmembrane protein is expressed on lymphocytes, macrophages, dendritic cells, monocytes, granulocytes, and thymic stromal cells. CD54 is also present on endothelial cells and such non-immune cells as hepatocytes, cardiomyocytes, and vascular smooth muscle cells. In addition, reports demonstrate that CD54 expression can be induced in vitro by proinflammatory cytokines, including IFN-gamma, IL-1, CCL2, or TNF-alpha. CD54 plays important roles in transendothelial migration of leukocytes to sites of inflammation and in T cell interactions with antigen presenting cells. Studies indicate that CD54 mediates these functions by binding to lymphocyte function-associated molecule (LFA-1; also known as CD11a/CD18).
The 1A29 antibody has been reported to block interactions between CD54 and LFA-1.
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