The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human tau that contains threonine 217.
Conjugate
Unconjugated
Form
Liquid
Purification
purified
Storage buffer
PBS, pH 7.4, with 1mg/ml BSA
Preservative
0.05% sodium azide
Storage Conditions
-20°C
Tested Applications
Dilution *
Flow Cytometry (Flow)
3-5 µg/million cells
Immunohistochemistry (Paraffin) (IHC (P))
1:20-1:200
Western Blot (WB)
0.1-1.0 ug/ml
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Background/Target Information
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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