A chemically synthesized phosphopeptide derived from a region of human Vav1 that contains tyrosine 160
Conjugate
Unconjugated
Form
Liquid
Purification
purified
Storage buffer
Dulbecco's PBS, pH 7.3, with 1mg/ml BSA
Preservative
0.05% sodium azide
Storage Conditions
-80°C
Tested Applications
Dilution *
Western Blot (WB)
0.1-1.0 ug/ml
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Background/Target Information
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
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