PHOSPHO-MEK1/MEK2 (SER222) PAB 10 BLOT BIOSOURCE (TM)

Background/Target Information

MAP2K1 is a dual specificity mitogen-activated protein kinase (MAPK) kinase. It is an essential component of the MAP kinase pathway and stimulates the enzymatic activity of MAP kinases in response to various signals. Growth factors, cytokines, and proto-oncogenes transduce their signals through the activation of RAS, which leads to activation of the serine/threonine kinase RAF, and then to activation of MAPK kinase. MAP2K1 is activated by the Raf family member p74raf-1, through phosphorylation of serine residues at positions 217 and 221 in the activation loop.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Gene Aliases:

AA589381, MAPKK1, MAPKK2, MEK1, PRKMK1, Mek1, CFC4, MEK2, PRKMK2, Prkmk1, Prkmk2, CFC3, MEKK1, MKK1, MKK2, MK2

Protein Aliases:

ERK activator kinase 2, MAP kinase kinase 2, MAPK/ERK kinase 2, MAPKK 2, MEK 2, MEK2, dual specificity mitogen-activated protein kinase kinase 2, MAP kinase/Erk kinase, mitogen activated protein kinase kinase 2, protein kinase, mitogen activated, kinase 2, p45, mitogen-activated protein kinase kinase 2, p45, ERK activator kinase 1, MAP kinase kinase 1, MAPK/ERK kinase 1, MAPKK 1, MEK 1, dual specificity mitogen-activated protein kinase kinase 1, mitogen activated protein kinase kinase 1, protein kinase, mitogen activated, kinase 1, p45, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1), MAP kinase/Erk kinase 1, mitogen-activated protein kinase kinase 1, MAP2K1, Map2k2, mitogen-activated kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, MKK2, PRKMK2

Entrez Gene ID:

(Human) 5604, (Human) 5605, (Rat) 170851, (Mouse) 26395, (Mouse) 26396, (Rat) 58960

UniProt ID:

(Human) Q02750, (Human) P36507, (Rat) Q01986, (Mouse) P31938, (Mouse) Q63932, (Rat) P36506

Biological Process -

 Protein metabolism and modification  Protein modification  Protein phosphorylation  Signal transduction  Intracellular signaling cascade  MAPKKK cascade

Molecular Function -

 Kinase  Protein kinase