IgA (Immunoglobulin A) represents only 10-15% of the total Ig molecules in serum but is the predominating Ig isotype in saliva, tears, breast milk and in the gastrointestinal and urogenital tract. In serum, the IgA molecule is commonly found as a monomer of either IgA1 or IgA2 subclass but can also exist as dimers or larger polymeric forms. The IgA found in secretions (secretory IgA) is commonly a dimer with two IgA molecules joined by the J chain. Secretory IgA is the most important Ig isotype in mucous surfaces, the area of entry for most pathogens.
ELISpot Plus kit for enumeration of total and antigen-specific IgA producing cells. The kit contains 4 ELISpot plates with PVDF membrane, capture mAb, biotinylated detection pAb, Streptavidin-HRP, polyclonal activators (R848 and recombinant human IL-2) and TMB substrate.
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