Synthetic peptide derived from the C-terminal region of human IRAK1( Interleukin 1 receptor-associated kinase 1)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.25 mg/ml
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Preservative
0.1% sodium azide
Storage Conditions
-20°C
Tested Applications
Dilution *
Flow Cytometry (Flow)
3-5 µg/million cells
Immunocytochemistry (ICC)
1µg/mL
Immunofluorescence (IF)
1µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
1:20-1:200
Western Blot (WB)
1-2 µg/ml
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Background/Target Information
Nuclear factor kappa B (NF-kappa B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa B mediates the expression of a great variety of genes in response to extracellular stimuli including interleukin-1 (IL-1), tumor necrosis factor alpha (TNF alpha) , and lipopolysaccarides (LPS). A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kappa B activation by members in the IL-1 family including IL-1 and a novel cytokine IL-18.
原厂资料：
注意事项：
For Research Use Only. Not for use in diagnostic procedures.
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