* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
37-8200 detects Phospho-Progesterone Receptor in Human samples.
37-8200 has been successfully used in western blot, immunofluorescence and immunohistochemistry in human samples. Phospho-Progesterone Receptor (Ser 190) antibody detects both progesterone receptor A and B forms when phosphorylated at Ser26 and Ser190, respectively.
Background/Target Information
The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription.
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注意事项：
For Research Use Only. Not for use in diagnostic procedures.
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