Apolipoprotein E (apoE) is a 34 kD heparin binding glycoprotein involved in lipid transport and lipoprotein metabolism. It is present in plasma lipoprotein particles such as chylomicrons, VLDL and HDL. ApoE is also present in large amounts at sites of neurological damage and appears to be involved in recycling of apoptotic remnants and of amyloidal aggregates. ApoE is mainly produced in the liver and by macrophages, but also by other cell types such as smooth muscle cells or neuronal cells. ApoE exists in three isoforms, apoE2, apoE3 and apoE4. Of these, apoE4 is associated with Alzheimer’s disease.
ELISpot PLUS kit for the detection of human apolipoprotein E. This complete kit contains ELISpot plates with PVDF membrane, capture mAb, biotinylated detection mAb, Streptavidin-ALP and BCIP/NBT substrate.
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