Interleukin-21 (IL-21) is primarily secreted by CD4+ T cells (in particular follicular T cells and Th17) and is an important regulator of immune responses; for Th17 cells, IL-21 is an autocrine regulator sustaining Th17 development. IL-21 also regulates the development of other T cells as well as B cells, NK cells and dendritic cells. Areas of particular interest for research on IL-21 include autoimmune and inflammatory diseases, cancer research but also basic studies on e.g. B cells and T cells, in particular Th17 cells.
ELISpot PLUS kit for the detection of human IL-21. This complete kit contains ELISpot plates with PVDF membrane, capture mAbs, biotinylated detection mAb, Streptavidin-HRP and TMB substrate.