Interleukin-21 (IL-21) is primarily secreted by CD4+ T cells (in particular follicular T cells and Th17) and is an important regulator of immune responses; for Th17 cells, IL-21 is an autocrine regulator sustaining Th17 development. IL-21 also regulates the development of other T cells as well as B cells, NK cells and dendritic cells. Areas of particular interest for research on IL-21 include autoimmune and inflammatory diseases, cancer research but also basic studies on e.g. B cells and T cells, in particular Th17 cells.
ELISA kit for quantitative determination of native and recombinant human IL-21 in cell culture supernatants. The kit contains capture mAbs, biotinylated detection mAb, streptavidin-enzyme conjugate HRP and a cytokine standard.
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