Interleukin-17A (IL-17A) is a potent proinflammatory cytokine produced by activated Th17 (T-helper 17) cells and certain cells belonging to the innate immune system. Th17 cells play an important role in autoimmune diseases and protection against bacteria and fungi. IL-17A acts on a broad range of cell types to induce expression of cytokines, chemokines and metalloproteinases. As a result, secretion of IL-17A promotes inflammatory responses, which leads to the recruitment of neutrophils, enhancement of antibody production and activation of T cells. Increased expression of IL-17A is seen in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. It is also associated with asthma, psoriasis, cancer and transplant rejection.
Cross-reactivity has been assessed and confirmed with Rhesus and Cynomolgus macaques.
Mouse monoclonal antibody to monkey and human Interleukin-17A, clone MT241. Suitable as capture antibody in ELISA and ELISpot (in combination with clone MT504 biotinylated, code 3520-6).
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