Interleukin-17A (IL-17A) is a potent proinflammatory cytokine produced by activated Th17 (T-helper 17) cells and certain cells belonging to the innate immune system. Th17 cells play an important role in autoimmune diseases and protection against bacteria and fungi. IL-17A acts on a broad range of cell types to induce expression of cytokines, chemokines and metalloproteinases. As a result, secretion of IL-17A promotes inflammatory responses, which leads to the recruitment of neutrophils, enhancement of antibody production and activation of T cells. Increased expression of IL-17A is seen in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. It is also associated with asthma, psoriasis, cancer and transplant rejection.
ELISpot PLUS kit for the detection of human IL-17A. This complete kit contains ELISpot plates with PVDF membrane, monoclonal capture antibody, monocl. biotin. detection antibody, Streptavidin-ALP, BCIP/NBT substrate and anti-CD3 mAb as positive control.
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