Interleukin-23 (IL-23) is a disulfide-linked heterodimer which consists of a unique p19 subunit and the p40 subunit of IL-12. IL-23 is a proinflammatory cytokine, which is produced by macrophages and dendritic cells upon infections with certain pathogens. The IL-23 receptor is expressed on Th17 cells and IL-23 is responsible for Th17 expansion and stabilization.
All kits include a recombinant cytokine standard. No international standard exists for calibration.
Mabtech’s enzyme-linked immunosorbent assay, ELISA PRO, is a complete kit for the quantification of human IL-23 in biological fluids such as serum, plasma and cell culture supernatants. The assay utilizes ELISA strip plates precoated with a capture monoclonal antibody (mAb), a biotinylated mAb for detection, streptavidin-horseradish peroxidase (SA-HRP), TMB substrate, cytokine standard, buffers, diluents, stop solution and adhesive plate covers.