Interleukin-23 (IL-23) is a disulfide-linked heterodimer which consists of a unique p19 subunit and the p40 subunit of IL-12. IL-23 is a proinflammatory cytokine, which is produced by macrophages and dendritic cells upon infections with certain pathogens. The IL-23 receptor is expressed on Th17 cells and IL-23 is responsible for Th17 expansion and stabilization.
All kits include a recombinant cytokine standard. No international standard exists for calibration.
ELISA kit for quantitative determination of native and recombinant human IL-23 in biological fluids such as serum, plasma and cell culture supernatants. The kit contains capture mAbs, biotinylated detection mAb, streptavidin-enzyme conjugate ALP and a cytokine standard. The determination of IL-23 in human serum/plasma samples by this kit requires the use of ELISA diluent (code: 3652-D2) for dilution of samples, standard and detection antibody.