Interleukin-12 (IL-12) is, when biologically active, a heterodimer (p70) consisting of two covalently linked subunits, p35 and p40. The p40 subunit is shared with IL-23. IL-12 is produced by antigen-presenting cells, specifically dendritic cells and macrophages. IL-12 is a proinflammatory cytokine that promotes TH1-type responses by inducing IFN-ã production and enhancing proliferation and cytotoxicity of NK and T cells.
Please check our different ELISA kits for the detection of mouse IL-12 p70 below. All kits include a recombinant cytokine standard. No international standard exists for calibration.
ELISA kit for quantitative determination of native and recombinant mouse IL-12 p70 in biological fluids such as serum, plasma and cell culture supernatants. The kit contains capture mAb, biotinylated detection mAb, streptavidin-enzyme conjugate HRP and a recombinant IL-12 standard (p70 heterodimer).