Interferon-alpha (IFN-α) is produced by multiple cell types in response to viral infection and constitutes an important part of the innate immune response. There are multiple human IFN-α genes of which at least 13 are transcribed. This results in 12 different functional IFN-α subtype proteins since IFN-α 1 and IFN-α 13 are identical. The IFN-α subtypes display high homology with each other but differ to various extents with regard to the type of producer cells and their anti-viral capacity. The subtype specificity of antibodies to IFN-α differs and needs to be defined for each antibody or for each capture/detection antibody combination. The pan specific system is based on multiple antibodies to detect 11 out of 12 IFN-α subtypes (1, 2, 4, 5, 6, 7, 8, 10, 14, 16 and 17).
Reacts with Human, cross reacts with certain non-human primates.
Mouse monoclonal antibodies to human Interferon-α (pan specific), clones MT2/4/6 biotinylated. Suitable as detection antibodies in ELISA and ELISpot (in combination with clones MT1/3/5, code 3425-3). *Based on multiple antibodies to detect a broad panel of IFN-α subtypes; reactive with all IFN-α subtypes except subtype 21.
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