IgG (Immunoglobulin G) is the most abundant Ig isotype in serum and makes up approximately 80% of all serum Immunoglobulins. In humans, there are four subclasses of IgG with highest serum concentrations of IgG1 followed by IgG2, IgG3 and IgG4. The IgG molecule consists of two heavy and two lights chains (κ or λ) resulting in a molecule with two arms for antigen binding. High levels of IgG antibodies are induced following the initial IgM response in a typical immune response to antigens.
For monoclonal antibodies and ELISA kits, cross-reactivity has been assessed and confirmed with certain non-human primate species. Please consult this comprehensive table for information about cross-reactivities with non-human primates.
Application guide:
Monoclonal antibodies to human IgG