A fusion protein consisting of the first 203 amino-terminal residues of the mouse RanGAP-1 protein.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/ml
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Preservative
0.1% sodium azide
Storage Conditions
-20°C
Tested Applications
Dilution *
ELISA (ELISA)
0.1-1.0 ug/ml
Flow Cytometry (Flow)
3-5 ug x 10^6 cells
Immunofluorescence (IF)
1-2 µg/ml
Western Blot (WB)
0.1-1.0 ug/ml
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
原厂资料：
注意事项：
For Research Use Only. Not for use in diagnostic procedures.
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