Description: This HLy9.25 monoclonal antibody reacts with human CD229 (also known as Ly9 or SLAMF3), an approximately 120-kDa member of the Signaling Lymphocyte Activation Molecule (SLAM) immunoglobulin superfamily. This type I transmembrane glycoprotein is expressed on a variety of immune cell types, including thymocytes, T and B lymphocytes, and natural killer cells. Expression of CD229 is also detected on T and B cell malignancies, including Jurkat and Burkitt lymphoma cells, respectively. CD229 has been shown to interact with SH2-binding phosphatases and the adaptor proteins SLAM-associated protein (SAP) and EAT-2. Moreover, CD229 localizes to the immunological synapse following T cell activation.
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